Welcome to the new version of CaltechAUTHORS. Login is currently restricted to library staff. If you notice any issues, please email coda@library.caltech.edu
Published April 2017 | Published
Journal Article Open

Use of a single xenon flash lamp for photoacoustic computed tomography of multiple-centimeter-thick biological tissue ex vivo and a whole mouse body in vivo


While lasers have been commonly used as illumination sources in photoacoustic (PA) imaging, their high purchase and maintenance costs, as well as their bulkiness, have hindered the rapid clinical dissemination of PA imaging. With this in mind, we explore an alternative illumination source for PA tomography—a xenon flash lamp with high pulse energy and a microsecond pulse width. We demonstrate that, by using a single xenon flash lamp, we can image both a black latex cord placed in chicken breast tissue at a depth of up to 3.5 cm ex vivo and an entire mouse body in vivo. Our findings indicate that the xenon flash lamp, producing optical illumination that is safe for humans, can be potentially applied to human tissue imaging.

Additional Information

© 2017 Society of Photo-Optical Instrumentation Engineers. Paper 160575SSR received Aug. 24, 2016; accepted for publication Oct. 10, 2016; published online Oct. 24, 2016. The authors appreciate Professor James Ballard's close reading of this paper and Dr. Teng Li's experimental assistance. This work was sponsored in part by the National Institutes of Health under Grant Nos. DP1 EB016986 (NIH Director's Pioneer Award), R01 CA186567 (NIH Director's Transformative Research Award), and R01 EB016963. L.W. has a financial interest in Microphotoacoustics, Inc., which, however, did not support this work. K.M. has a financial interest in Microphotoacoustics, Inc.

Attached Files

Published - 041003_1.pdf


Files (3.1 MB)
Name Size Download all
3.1 MB Preview Download

Additional details

August 21, 2023
October 18, 2023