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Published March 22, 2003 | public
Journal Article

Cellerator: extending a computer algebra system to include biochemical arrows for signal transduction simulations


Cellerator describes single and multi-cellular signal transduction networks (STN) with a compact, optionally palette-driven, arrow-based notation to represent biochemical reactions and transcriptional activation. Multi-compartment systems are represented as graphs with STNs embedded in each node. Interactions include mass-action, enzymatic, allosteric and connectionist models. Reactions are translated into differential equations and can be solved numerically to generate predictive time courses or output as systems of equations that can be read by other programs. Cellerator simulations are fully extensible and portable to any operating system that supports Mathematica, and can be indefinitely nested within larger data structures to produce highly scaleable models.

Additional Information

© 2003 Oxford University Press. Received May 30, 2002. Accepted November 4, 2002. Revision received September 26, 2002. Portions of this research were carried out by the Jet Propulsion Laboratory, California Institute of Technology, under contract with NASA. Availability: Cellerator can be licensed free of charge to noncommercial academic, U.S. government, and nonprofit users. Details and sample notebooks are available at http://www-aig.jpl.nasa.gov/public/mls/cellerator.

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