Published June 15, 2004
| Published
Journal Article
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Protein-based molecular contrast optical coherence tomography with phytochrome as the contrast agent
Abstract
We report the use of phytochrome A (phyA), a plant protein that can reversibly switch between two states with different absorption maxima (at 660 and 730 nm), as a contrast agent for molecular contrast optical coherence tomography (MCOCT). Our MCOCT scheme builds up a difference image revealing the distribution of phyA within a target sample from pairs of consecutive OCT A-scans acquired at a probe wavelength of 750 nm, both with and without additional illumination of the target sample with 660-nm light. We demonstrate molecular imaging with this new MCOCT modality in a target sample containing a mixture of 0.2% Intralipid and 83 µM of phyA.
Additional Information
© 2004 Optical Society of America. Received January 2, 2004. This research was supported by National Institutes of Health grant EB000243.Attached Files
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Additional details
- Eprint ID
- 3323
- Resolver ID
- CaltechAUTHORS:YANol04b
- NIH
- EB000243
- Created
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2006-05-30Created from EPrint's datestamp field
- Updated
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2020-03-09Created from EPrint's last_modified field