Published April 3, 2015
| Accepted Version
Journal Article
Open
A prudent path forward for genomic engineering and germline gene modification
- Creators
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Baltimore, David
- Berg, Paul
- Botchan, Michael
- Carroll, Dana
- Alto Charo, R.
- Church, George
- Corn, Jacob E.
- Daley, George Q.
- Doudna, Jennifer A.
- Fenner, Marsha
- Greely, Henry T.
- Jinek, Martin
- Martin, G. Steven
- Penhoet, Edward
- Puck, Jennifer
- Sternberg, Samuel H.
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Weissman, Jonathan S.
- Yamamoto, Keith R.
Abstract
A framework for open discourse on the use of CRISPR-Cas9 technology to manipulate the human genome is urgently needed.
Additional Information
© 2015 American Association for the Advancement of Science. Published online March 19 2015. J.A.D. and M.J. are cofounders of Caribou Biosciences, Inc., which develops CRISPR-Cas technology for genome engineering for agricultural and biomedical applications. J.A.D. and M.J. are on the Scientific Advisory Board of Caribou Biosciences, Inc. G.C. has been an advisor to Caribou Biosciences, Inc. G.C. and J.A.D. are cofounders of, and G.C. is a member of the Scientific Advisory Board of, Editas Medicine, a company that translates genome editing technology into human therapeutics. G.C. has been an advisor to Sigma-Aldrich, which sells products related to CRISPR-Cas technology. D.C. is on the Scientific Advisory Board of Recombinetics, Inc., which develops genome engineering approaches for agricultural and biomedical applications. E.P. is director of Alta Partners, Ltd., a shareholder in Kite Pharmaceuticals, which develops genome engineering for biomedical applications. G.C. is an inventor on patents filed by Harvard University that cover the use of Cas9 in human cells, and reduction in off-target activity. J.A.D. is an inventor on patents filed by the University of California for research and development on CRISPR-Cas9–mediated genome engineering. J.S.W. is an inventor on patents filed by the University of California, San Francisco, the University of California, Berkeley, and the Howard Hughes Medical Institute, that cover CRISPR screening technology.Attached Files
Accepted Version - nihms677725.pdf
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Additional details
- PMCID
- PMC4394183
- Eprint ID
- 55938
- Resolver ID
- CaltechAUTHORS:20150319-185722928
- Created
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2015-03-20Created from EPrint's datestamp field
- Updated
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2022-06-14Created from EPrint's last_modified field