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Published October 24, 1995 | Published
Journal Article Open

Identification of a Drosophila muscle development gene with structural homology to mammalian early growth response transcription factors


In Drosophila, stripe (sr) gene function is required for normal muscle development. Some mutations disrupt embryonic muscle development and are lethal. Other mutations cause total loss of only a single muscle in the adult. Molecular analysis shows that sr encodes a predicted protein containing a zinc finger motif. This motif is homologous to the DNA binding domains encoded by members of the early growth response (egr) gene family. In mammals, expression of egr genes is induced by intercellular signals, and there is evidence for their role in many developmental events. The identification of sr as an egr gene and its pattern of expression suggest that it functions in muscle development via intercellular communication.

Additional Information

© 1995 National Academy of Sciences. Communicated by Gunther S. Stent, University of California, Berkeley, CA, June 27, 1995 (received for review May 2, 1995) We thank A. Kolodkin for stock sr^(B14.0) and genomic DNA clones; C. Oh, E. Reynolds, and P. Pavlidis for comments on the manuscript and technical advice; M. Palazzolo for technical advice; S. Faulhaber, A. Francisco, D. Chang, and R. Young for technical assistance; and S. Benzer for use of laboratory facilities. This work was supported in part by Public Health Service National Research Service Award GM15867-02 to J.C.L. and by grants from the Department of Biotechnology, Government of India, and the Rockefeller Foundation to KV. The publication costs of this article were defrayed in part by page charge payment. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. §1734 solely to indicate this fact.

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