Welcome to the new version of CaltechAUTHORS. Login is currently restricted to library staff. If you notice any issues, please email coda@library.caltech.edu
Published October 2011 | Published
Journal Article Open

Functional photoacoustic microscopy of pH


pH is a tightly regulated indicator of metabolic activity. In mammalian systems, an imbalance of pH regulation may result from or result in serious illness. In this paper, we report photoacoustic microscopy (PAM) of a commercially available pH-sensitive fluorescent dye (SNARF-5F carboxylic acid) in tissue phantoms. We demonstrated that PAM is capable of pH imaging in absolute values at tissue depths of up to 2.0 mm, greater than possible with other forms of optical microscopy.

Additional Information

© 2011 Society of Photo-Optical Instrumentation Engineers (SPIE). Paper 11186LRR received Apr. 12, 2011; revised manuscript received Aug. 24, 2011; accepted for publication Sep. 9, 2011; published online Oct. 14, 2011. The authors thank James Ballard and Sandra Matteucci for help in manuscript edition. This work was supported in part by National Institutes of Health Grant Nos. U54CA136398 and R01 EB000712. L. V. Wang has a financial interest in Microphotoacoustics, Inc. and Endra, Inc, which, however, did not support this work.

Attached Files

Published - 100503_1.pdf


Files (1.0 MB)
Name Size Download all
1.0 MB Preview Download

Additional details

August 22, 2023
October 18, 2023