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Published September 28, 2005 | Supplemental Material
Journal Article Open

A Steroid-Conjugated Contrast Agent for Magnetic Resonance Imaging of Cell Signaling


We have synthesized the first steroid hormone−MR contrast agent conjugate designed to track the cell signaling process upon binding to a gene switch system. The derivative has a high relaxivity and when tested in vitro is active as a progesterone antagonist (RU-486). By combining a transcriptional system and a noninvasive imaging technology, such as MRI, it would be a powerful tool to research the cell signaling pathway in vivo.

Additional Information

© 2005 American Chemical Society. Received March 1, 2005. We thank Scott Fraser for helpful discussions, Keith MacRenaris for ICP-MS analysis, Steve Bull for image acquisition and T_1 analysis, and Ken Korach for providing PRE-luciferase. This work is supported by the National Institutes of Health (5RO1 A147003, DOD 91008600, and PO1HD021921), and by Northwestern University Reproductive Biology Training Grant T32 HD007068.

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Supplemental Material - ja051294xsi20050805_082914.pdf


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