Published September 28, 2005
| Version Supplemental Material
Journal Article
Open
A Steroid-Conjugated Contrast Agent for Magnetic Resonance Imaging of Cell Signaling
Creators
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1.
Northwestern University
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2.
California Institute of Technology
Abstract
We have synthesized the first steroid hormone−MR contrast agent conjugate designed to track the cell signaling process upon binding to a gene switch system. The derivative has a high relaxivity and when tested in vitro is active as a progesterone antagonist (RU-486). By combining a transcriptional system and a noninvasive imaging technology, such as MRI, it would be a powerful tool to research the cell signaling pathway in vivo.
Additional Information
© 2005 American Chemical Society. Received March 1, 2005. We thank Scott Fraser for helpful discussions, Keith MacRenaris for ICP-MS analysis, Steve Bull for image acquisition and T_1 analysis, and Ken Korach for providing PRE-luciferase. This work is supported by the National Institutes of Health (5RO1 A147003, DOD 91008600, and PO1HD021921), and by Northwestern University Reproductive Biology Training Grant T32 HD007068.Attached Files
Supplemental Material - ja051294xsi20050805_082914.pdf
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Additional details
Identifiers
- Eprint ID
- 55669
- Resolver ID
- CaltechAUTHORS:20150310-113015676
Funding
- NIH
- 5RO1 A147003
- NIH
- DOD 91008600
- NIH
- PO1HD021921
- Northwestern University Reproductive Biology Training Grant
- T32 HD007068
Dates
- Created
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2015-03-10Created from EPrint's datestamp field
- Updated
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2021-11-10Created from EPrint's last_modified field