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Published February 23, 2010 | Published
Book Section - Chapter Open

Tissue temperature monitoring using thermoacoustic and photoacoustic techniques


Real-time temperature monitoring with high spatial resolution (~1 mm) and high temperature sensitivity (1 °C or better) is needed for the safe deposition of heat energy in surrounding healthy tissue and efficient destruction of tumor and abnormal cells during thermotherapy. A temperature sensing technique using thermoacoustic and photoacoustic measurements combined with a clinical Philips ultrasound imaging system (iU22) has been explored in this study. Using a tissue phantom, this noninvasive method has been demonstrated to have high temporal resolution and temperature sensitivity. Because both photoacoustic and thermoacoustic signal amplitudes depend on the temperature of the source object, the signal amplitudes can be used to monitor the temperature. The signal is proportional to the dimensionless Grueneisen parameter of the object, which in turn varies with the temperature of the object. A temperature sensitivity of 0.5 °C was obtained at a temporal resolution as short as 3.6 s with 50 signal averages.

Additional Information

© 2010 Society of Photo-Optical Instrumentation Engineers (SPIE). This work was sponsored by National Institutes of Health grants No. R01 EB000712, No. R01 NS46214 (Bioengineering Research Partnerships), No. R01 EB008085, and No. U54 CA136398 (Network for Translational Research). We thank John Dean, Victor Gornstein, and Adam Schleicher for modifying the Philips iU22 ultrasound imaging system used for thermoacoustic imaging. LVW has a financial interest in Microphotoacoustics, Inc. and Endra, Inc., which, however, did not support this work. TNE and LJ are employees of Philips Research.

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