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Published January 1, 2013 | Published
Journal Article Open

Integrated optical- and acoustic-resolution photoacoustic microscopy based on an optical fiber bundle


Photoacoustic microscopy (PAM), whose spatial resolution and maximum imaging depth are both scalable, has made great progress in recent years. However, each PAM system currently achieves only one resolution with an associated maximum imaging depth. Here, we present an integrated optical-resolution (OR) and acoustic-resolution (AR) PAM system implemented by delivering light via an optical fiber bundle. A single fiber core is used to deliver light for OR illumination in order to achieve a small spot size and hence high lateral resolution, whereas all the fiber cores are used to deliver more energy for AR illumination. Most other components are shared by the OR and AR imaging. The lateral resolution can be seamlessly switched between 2.2 and 40 μm as the maximum imaging depth is switched between 1.3 and 3.0 mm. The system enables automatically coregistered higher-resolution OR and deeper AR photoacoustic imaging.

Additional Information

© 2012 Optical Society of America. Received August 30, 2012; revised November 15, 2012; accepted November 27, 2012; posted December 4, 2012 (Doc. ID 175121); published December 20, 2012. This work was sponsored by National Institutes of Health (NIH) grants R43 HL106855, R01 EB000712, R01 EB008085, R01 CA134539, U54 CA136398, R01 CA157277, and R01 CA159959, as well as the Cancer Frontier Fund. L. V. Wang has a financial interest in Microphotoacoustics, Inc., and Endra, Inc., which did not support this work. K. Maslov has a financial interest in Microphotoacoustics, Inc., which did not support this work. The authors appreciate Prof. James Ballard's close reading of the manuscript.

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