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Published December 1993 | public
Journal Article

Drosophila protein tyrosine phosphatases

Zinn, Kai ORCID icon


Seven protein tyrosine phosphatase (PTPase) genes have been identified in the fruit-fly Drosophila melanogaster. Four of these genes encode receptor-linked PTPases (R-PTPs) that are expressed on central nervous system axons in the embryo. Each axonal R-PTP has an extracellular domain that is homologous to vertebrate adhesion molecules and to identified mammalian R-PTPs. Two non-receptor PTPase genes have been isolated to date. One of these, corkscrew (csw), encodes an SH2 domain-containing PTPase that appears to be a homolog of mammalian PTP1D. Genetic evidence indicates that the csw PTPase is involved in the transduction of signals from receptor tyrosine kinases to their down-stream targets, which include Ras proteins.

Additional Information

© 1993 Academic Press. I thank William Chia, Iswar Hariharan, Norbert Perrimon, Sharon McLaughlin, Jack Dixon, Shin-Shay Tian, Chand Desai, Sarah Fashena, Bruce Hamilton and Te-Yi Kung for helpful discussions and for communicating data before publication. Work in the author's laboratory was supported by National Institutes of Health RO1 grant # NS28182, as well as by Basil O'Connor Starter Scholar Research Award # 5-816 from the March of Dimes Birth Defects Foundation, a Pew Scholars Award and a McKnight Scholars Award.

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October 25, 2023