Electrocatalytic Asymmetric Nozaki–Hiyama–Kishi Decarboxylative Coupling: Scope, Applications, and Mechanism

This work was supported by the NSF Center for Synthetic Organic Electrochemistry, CHE-2002158 (the discovery and optimization effort). NIGMS (GM-118176) supported the scope and application study. A.C.H. was supported by an NSF Ascend fellowship (award number: 2138035). The authors are grateful to Dr. Laura Pasternack (Scripps Research) for assistance with nuclear magnetic resonance (NMR) spectroscopy, to Dr. Jason Chen, Brittany Sanchez, and Quynh Nguyen Wong (Scripps Automated Synthesis Facility) for assistance with HRMS and chiral SFC analysis. Elemental analysis data were obtained from the CENTC Elemental Analysis Facility at the University of Rochester, funded by NSF CHE-0650456. Mass spectral data were acquired by field desorption ionization mass spectrometry using an JMS-T2000 AccuTOF GC-Alpha (JEOL, Inc). The purchase of the instrument was enabled by funds from DOW Next Generation Instrumentation (CCEC.DOWINSTR-1-GRANT.DOWINSTR). The authors would like to thank Jay Winkler for assistance with CV experiments and Mona Shahgoli for assistance with HRMS experiments, as well as the Caltech CCE NMR facility and Multiuser Mass Spectrometry Laboratory, which is also supported by the NSF CRIF program (CHE-0541745).