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Published September 1973 | Version Published
Journal Article Open

Growth of Pseudotypes of Vesicular Stomatitis Virus with N-Tropic Murine Leukemia Virus Coats in Cells Resistant to N-Tropic Viruses

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Abstract

Formation of pseudotypes between murine RNA tumor viruses and vesicular stomatitis virus (VSV) has been confirmed. Pseudotypes of VSV genomes coated by the surface envelope from an N-tropic tumor virus grew equally well in cells homozygous for either the Fv-1n or Fv-1b alleles. Therefore, the product of the Fv-1 locus, which restricts growth of murine RNA tumor viruses, must act on an intracellular aspect of tumor virus replication, a step after attachment and penetration.

Additional Information

© 1973 by the American Society for Microbiology. Received for publication 19 June 1973. We thank Mort Litt and S.M. Perlman for help with antiserum and viral preparations and Tazwell Wilson for excellent technical assistance. We are especially grateful to Janet Hartley for supplying N-tropic MuLV. This work was supported by a National Science Foundation research grant GB 34266, American Cancer Society research grants VC-63 and VC-4D, and a contract from the Viral Cancer Program. A.S.H. is a Research Career Development Awardee of the Public Health Service (AI 70413). P.B. was supported by the Schweizerische Krebsliga. D.B. is an American Cancer Society Professor of Microbiology. This work grew out of a summer sojourn at the Salk Institute for Biological Studies.

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Additional details

Identifiers

PMCID
PMC356675
Eprint ID
10912
Resolver ID
CaltechAUTHORS:HUAjvir73

Funding

NIH
GB 34266
American Cancer Society
VC-63
American Cancer Society
VC-4D
Viral Cancer Program
NIH
AI 70413
Schweizerische Krebsliga

Dates

Created
2008-06-16
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Updated
2023-06-02
Created from EPrint's last_modified field