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Published May 15, 1998 | public
Journal Article

A comparison of H-pin and hairpin polyamide motifs for the recognition of the minor groove of DNA


Solid-phase polyamide synthesis is extended to the H-pin motif using a Boc-protected bispyrrole monomer and bidirectional synthesis. Sequence-specific recognition of a designated seven base pair target site is achieved by the formation of a 10-ring H-pin polyamide⋅DNA complex in the minor groove. DNA binding properties are compared with the corresponding hairpin polyamides (see below).

Additional Information

© 1998 Wiley-VCH Verlag GmbH. Received: November 20, 1997; First published: 15 May 1998. We are grateful to the National Institutes of Health (GM-27681) for support of the research and a research traineeship award (GM-08501) for W.A.G., to the Ralph M. Parsons Foundation for a predoctoral fellowship to W.A.G., and to the Howard Hughes Medical Institute for a predoctoral fellowship to E.E.B.

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