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Published November 1981 | Published
Journal Article Open

Porcine pituitary dynorphin: complete amino acid sequence of the biologically active heptadecapeptide


The full primary structure of the very potent opioid peptide dynorphin, from porcine pituitary, has been determined. It is (H)Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp-Asp-Asn-Gln(OH). The synthetic peptide with this sequence behaves identically to natural dynorphin in a number of ways, and it has the same potency in the guinea pig ileum myenteric plexus-longitudinal muscle bioassay. The potency is accounted for by the first 13 residues.

Additional Information

© 1981 by the National Academy of Sciences. Contributed by Avram Goldstein, August 24, 1981. We acknowledge the skilled technical assistance provided by Patricia Lowery, Asha Naidu, Keiko Otsu, and Vince Farnsworth. This investigation was supported by Grant DA-1199 from the National Institute on Drug Abuse (to A.G.), a grant from the Swiss National Foundation (to W.F.), a grant from the Weingart Foundation (to L.H.), and a generous gift from David Fasken to the Addiction Research Foundation. The publication costs of this article were defrayed in part by page charge payment. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. §1734 solely to indicate this fact.

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