T-cell immunometabolism against cancer
- Creators
- Jiang, Shuai
- Yan, Wei
Abstract
T cells play critical roles in host defenses against cancer. External signals prompt activation of naïve T cells, triggering modulation of their immune functions. Emerging evidence reveals that distinct metabolic changes impact the immune functions of naïve and effector T cells, including CD4+ and CD8+ T cells. Since T cells appear to be key players in tumor progression, it is important to elucidate whether and how T-cell metabolic reprogramming might alter their impact on cancer progression. Here we briefly review the available knowledge regarding T cells in relation to cancer, focusing on the metabolic reprogramming of T cells and how this influences tumor progression. Emerging insights in this field are improving our understanding of the functional role of T-cell metabolic reprogramming in cancer. Further research could provide a critical foundation for new treatments targeting cancer metabolism.
Additional Information
© 2016 Elsevier Ireland Ltd. Received 18 July 2016, Revised 15 September 2016, Accepted 16 September 2016, Available online 21 September 2016.Additional details
- Eprint ID
- 70595
- Resolver ID
- CaltechAUTHORS:20160927-091300884
- Created
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2016-09-28Created from EPrint's datestamp field
- Updated
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2021-11-11Created from EPrint's last_modified field