Welcome to the new version of CaltechAUTHORS. Login is currently restricted to library staff. If you notice any issues, please email coda@library.caltech.edu
Published June 2022 | Supplemental Material
Journal Article Open

The emerging role of photoacoustic imaging in clinical oncology


Clinical oncology can benefit substantially from imaging technologies that reveal physiological characteristics with multiscale observations. Complementing conventional imaging modalities, photoacoustic imaging (PAI) offers rapid imaging (for example, cross-sectional imaging in real time or whole-breast scanning in 10–15 s), scalably high levels of spatial resolution, safe operation and adaptable configurations. Most importantly, this novel imaging modality provides informative optical contrast that reveals details on anatomical, functional, molecular and histological features. In this Review, we describe the current state of development of PAI and the emerging roles of this technology in cancer screening, diagnosis and therapy. We comment on the performance of cutting-edge photoacoustic platforms, and discuss their clinical applications and utility in various clinical studies. Notably, the clinical translation of PAI is accelerating in the areas of macroscopic and mesoscopic imaging for patients with breast or skin cancers, as well as in microscopic imaging for histopathology. We also highlight the potential of future developments in technological capabilities and their clinical implications, which we anticipate will lead to PAI becoming a desirable and widely used imaging modality in oncological research and practice.

Additional Information

© 2022 Nature Publishing Group. Accepted 23 February 2022; Published 23 March 2022. The authors thank R. Cao for useful discussions. The authors are also grateful to J. Ballard, D. Garrett and J. Olick-Gibson for close reading of the paper. Contributions: Both authors made substantial contributions to all aspects of the preparation of this manuscript. Competing interests: L.V.W. has a financial interest in Microphotoacoustics, Inc., CalPACT, LLC and Union Photoacoustic Technologies, Ltd., which, however, did not support this work. L.L. declares no competing interests. Peer review information: Nature Reviews Clinical Oncology thanks the anonymous reviewer(s) for their contribution to the peer review of this work.

Attached Files

Supplemental Material - 41571_2022_615_MOESM1_ESM.pdf


Files (630.7 kB)
Name Size Download all
630.7 kB Preview Download

Additional details

August 22, 2023
October 23, 2023