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Published November 17, 2004 | public
Journal Article

Direct Oxidative Heck Cyclizations: Intramolecular Fujiwara-Moritani Arylations for the Synthesis of Functionalized Benzofurans and Dihydrobenzofurans


No extra functionalization step is required for palladium(II)-catalyzed oxidative carbocyclizations like that shown, which provide highly substituted benzofuran and dihydrobenzofuran derivatives by net dehydrogenation. The mechanism is similar to that of Heck cyclizations. Products containing quaternary carbon stereocenters can be obtained in diastereomerically pure form.

Additional Information

© 2004 Wiley. Issue online: 17 November 2004; version of record online: 17 November 2004; manuscript Received: 13 July 2004. The authors wish to thank the NIH-NIGMS (R01 GM65961-01), the NSF (predoctoral fellowship to E.M.F.), Johnson and Johnson, Pfizer, Merck, Amgen, Research Corporation, Roche, GlaxoSmith-Kline, and Eli Lilly for generous funding.

Additional details

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