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Published June 2022 | Supplemental Material + Accepted Version
Journal Article Open

Flexible patch with printable and antibacterial conductive hydrogel electrodes for accelerated wound healing


Electrical stimulation can facilitate wound healing with high efficiency and limited side effects. However, current electrical stimulation devices have poor conformability with wounds due to their bulky nature and the rigidity of electrodes utilized. Here, a flexible electrical patch (ePatch) made with conductive hydrogel as electrodes to improve wound management was reported. The conductive hydrogel was synthesized using silver nanowire (AgNW) and methacrylated alginate (MAA), with the former chosen as the electrode material considering its antibacterial properties, and the latter used due to its clinical suitability in wound healing. The composition of the hydrogel was optimized to enable printing on medical-grade patches for personalized wound treatment. The ePatch was shown to promote re-epithelization, enhance angiogenesis, mediate immune response, and prevent infection development in the wound microenvironment. In vitro studies indicated an elevated secretion of growth factors with enhanced cell proliferation and migration ability in response to electrical stimulation. An in vivo study in the Sprague-Dawley rat model revealed a rapid wound closure within 7 days compared to 20 days of usual healing process in rodents.

Additional Information

© 2022 Elsevier Ltd. Received 3 November 2021, Revised 7 March 2022, Accepted 18 March 2022, Available online 14 April 2022, Version of Record 26 April 2022. The authors acknowledge funding from the National Institutes of Health (EB024403, EB023052, GM126831, and HL140618). Data availability: The experimental data required to reproduce the findings from this study will be made available to interested investigators upon request. The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Attached Files

Accepted Version - 1-s2.0-S0142961222001181-main_accepted.pdf

Supplemental Material - 1-s2.0-S0142961222001181-mmc1.docx


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August 22, 2023
October 24, 2023