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Published February 19, 2007 | Published
Book Section - Chapter Open

A high-resolution optofluidic microscope with optical tweezer actuation


In this paper, we will report our recent development of a new type of OptoFluidic Microscope (OFM) that is capable of delivering resolution beyond the diffraction limit of light. Accurate control of the sample translation is accomplished by adopting an optical tweezer scanner into the system. During the image acquisition, a two-dimensional nanoaperture array defined on a thin aluminum film acts as an array of ultra-fine illumination sources. The imaging system is tested and demonstrated by using polystyrene beads and green algae (Chlamydomonas). Properties of the system are reported and discussed.

Additional Information

© 2007 Society of Photo-Optical Instrumentation Engineers (SPIE). We are grateful to Xiquan Cui, Zahid Yaqoob, Jigang Wu and Lap Man Lee from Caltech for their generous help. We thank UCLA's Nanolab and Caltech's nanofabrication group (Dr. Scherer) for their assistance in fabrication. This work was funded by DARPA Center for Optofluidic Integration (California Institute of Technology) and Coulter Foundation Career Award (funding).

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August 19, 2023
January 14, 2024