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Published August 1999 | public
Journal Article

Energy functions for protein design


Recent successes in protein design have illustrated the promise of computational approaches. These methods rely on energy expressions to evaluate the quality of different amino acid sequences for target protein structures. The force fields optimized for design differ from those typically used in molecular mechanics and molecular dynamics calculations.

Additional Information

© 1999 Elsevier Science Ltd. Available online 22 September 1999. We wish to thank AG Street for helpful comments on the manuscript. This work was supported by the Howard Hughes Medical Institute (SLM), the Helen G and Arthur McCallum Foundation (DBG), a National Institutes of Health NRSA training grant and the Caltech Initiative in Computational Molecular Biology program, awarded by the Burroughs Wellcome Fund (SAM).

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August 19, 2023
October 23, 2023