Published January 22, 2002
| Version Published
Journal Article
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Life extension in Drosophila by feeding a drug
Abstract
We report that feeding Drosophila throughout adulthood with 4-phenylbutyrate (PBA) can significantly increase lifespan, without diminution of locomotor vigor, resistance to stress, or reproductive ability. Treatment for a limited period, either early or late in adult life, is also effective. Flies fed PBA show a global increase in histone acetylation as well as a dramatically altered pattern of gene expression, including induction or repression of numerous genes. The delay in aging may result from the altered physiological state.
Additional Information
© 2002 by the National Academy of Sciences. Contributed by Seymour Benzer, November 28, 2001. Published online before print January 15, 2002, 0.1073/pnas.022631999. We especially thank Joseph Cooper at Medicis (Scottsdale, AZ) for his generous gift of PBA. This research, initiated at Caltech, was supported by an intramural grant to K.-T.M. from the National Institute of Neurological Disorders and Stroke and the Ellison Foundation, and grants to S.B. from the National Science Foundation, the National Institutes of Health, the Ellison Foundation, and the James G. Boswell Foundation.Attached Files
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Additional details
Identifiers
- PMCID
- PMC117392
- Eprint ID
- 1617
- Resolver ID
- CaltechAUTHORS:KANpnas02
Funding
- NIH
- National Institute of Neurological Disorders and Stroke (NINDS)
- Ellison Medical Foundation
- NSF
- James G. Boswell Foundation
Dates
- Created
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2006-02-07Created from EPrint's datestamp field
- Updated
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2023-06-01Created from EPrint's last_modified field