Published April 2004
| public
Journal Article
Physical properties of artificial extracellular matrix protein films prepared by isocyanate crosslinking
- Creators
- Nowatzki, Paul J.
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Tirrell, David A.
Abstract
Artificial extracellular matrix proteins, genetically engineered from elastin- and fibronectin-derived repeating units, were crosslinked with hexamethylene diisocyanate in dimethylsulfoxide. The resulting hydrogel films were transparent, uniform, and highly extensible. Their tensile moduli depended on crosslinker concentration and spanned the range characteristic of native elastin. The water content of the films was low (∼27%), but the temperature-dependent swelling behavior of the crosslinked materials was reminiscent of the lower critical solution temperature property of the soluble polymers.
Additional Information
© 2003 Elsevier Ltd. Received 4 June 2003; accepted 25 July 2003. Published in issue: Volume 25, Issues 7–8, March–April 2004, Pages 1261–1267. Acknowledgments: This work was supported by the National Institutes of Health (R01-HL59987) and the National Science Foundation (BES-9901648).Additional details
- Eprint ID
- 54040
- Resolver ID
- CaltechAUTHORS:20150123-161424688
- NIH
- R01-HL59987-03
- NSF
- BES-9901648
- Created
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2015-01-24Created from EPrint's datestamp field
- Updated
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2021-11-10Created from EPrint's last_modified field