The HRI branch of the integrated stress response selectively triggers mitophagy

Abstract

Acknowledgement

We are grateful to A. Merchan, J. Repogle, J. Weissman, K. Page, R. She, and R. Voorhees for encouragement and advice on CRISPRi screening; D. Perez, J. Tijerina, and R. Diamond (Caltech Flow Cytometry and Cell Sorting Facility) for support with flow cytometry and FACS experiments; and I. Antoshechkin (Millard and Muriel Jacobs Genetics and Genomics Laboratory, Caltech) for support with next-generation sequencing. We thank the following investigators for contribution of important reagents: L. Jae, S. Yamashita, K. Yamano, N. Matsuda, G. Varuzhanyan, R. Youle, A. Ting, M. Moore, D. Ron, and J. Lippincott-Schwartz. We thank members of the Chan lab for helpful discussions and comments on the manuscript. This work was funded by the National Institutes of Health grant R35 GM127147 (D.C.C.).

Contributions

Conceptualization, Y.C. and D.C.C.; methodology, Y.C., Z.Y., and H.C.; investigation, Y.C., Z.Y., and H.C.; funding acquisition, D.C.C.; supervision, D.C.C.; writing – original draft, Y.C. and D.C.C.; writing – review & editing, Y.C., D.C.C., Z.Y., and H.C.

Conflict of Interest

The authors declare no competing interests.

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