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Published January 1, 1994 | metadata_only
Journal Article

Photomodulation of the inverse temperature transition of a modified elastin poly(pentapeptide)


The inverse temperature transition exhibited by elastin-like polypeptides has been shown to provide a basis for an intriguing array of energy transduction processes. For example, the elastin poly(pentapeptide) 1 can be fabricated into cross-linked gels that remain swollen in water at temperatures below 25 °C but then deswell, or contract, upon a rise in temperature. Modification of sequence 1 has produced a series of related polypeptides that undergo phase mixing or swelling transitions in response to changes in pH, ionic strength, pressure, and oxidation/reduction or upon enzymatic phosphorylation. We report herein the photomodulation of the inverse temperature transition of the modified elastin polypeptide 2b. This development provides a route to protein-based polymeric materials and gels capable of photomechanical transduction.

Additional Information

This work was supported in part by the NSF Materials Research Laboratory at the University of Massachusetts and by Contracts Nos. N00014-90-C-0265 and N00014-89-J-1970 from the Department of the Navy, Office of Naval Research. Luke A. Strzegowski held a fellowship provided by the Research Experiences for Undergraduates program of the MRL. Manuel Bueno Martinez was a Visiting Scientist from the University of Seville, Spain, and was supported by the DGICYT.

Additional details

August 22, 2023
August 22, 2023