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Published January 5, 2004 | public
Journal Article

Palladium-Catalyzed Oxidative Kinetic Resolution with Ambient Air as the Stoichiometric Oxidation Gas


Air is enough to mediate the highly enantioselective oxidation of secondary alcohols at room temperature with palladium(II) and sparteine in nonflammable solvents. Examination of the role of solvents capable of hydrogen bonding and their ability to solvate halide anions led to a novel set of conditions for the highly enantioselective oxidative kinetic resolution of secondary alcohols.

Additional Information

© 2004 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. Issue online: 29 December 2003; Version of record online: 29 December 2003; Manuscript Received: 22 July 2003. The authors thank the NIH-NIGMS (R01 GM65961-01), the University of California TRDRP (predoctoral fellowship to JTB), the Dreyfus Foundation, Merck Research Laboratories, Research Corporation, Abbott Laboratories, Eli Lilly, GlaxoSmithKline, Johnson and Johnson, Pfizer, and the A. P. Sloan Foundation for generous financial support.

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