Welcome to the new version of CaltechAUTHORS. Login is currently restricted to library staff. If you notice any issues, please email coda@library.caltech.edu
Published July 7, 2006 | Published
Journal Article Open

Molecular Sieving in Periodic Free-Energy Landscapes Created by Patterned Nanofilter Arrays


We present an experimental study of Ogston-like sieving process of rodlike DNA in patterned periodic nanofluidic filter arrays. The electrophoretic motion of DNA through the array is described as a biased Brownian motion overcoming periodically modulated free-energy landscape. A kinetic model, constructed based on the equilibrium partitioning theory and the Kramers theory, explains the field-dependent mobility well. We further show experimental evidence of the crossover from Ogston-like sieving to entropic trapping, depending on the ratio between nanofilter constriction size and DNA size.

Additional Information

© 2006 The American Physical Society (Received 22 December 2005; published 7 July 2006) We acknowledge support from NSF (No. CTS-0347348), NIH (No. EB005743), and Singapore-MIT Alliance (SMA-II, CE program). J.Y. was supported by the Caltech Summer Undergraduate Research Program. We thank P. Mao for helping take the SEM images.

Attached Files

Published - FUJprl06.pdf


Files (531.7 kB)
Name Size Download all
531.7 kB Preview Download

Additional details

August 22, 2023
October 16, 2023