Published June 1977
| Version Published
Journal Article
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Rates of formation and thermal stabilities of RNA:DNA and DNA:DNA duplexes at high concentrations of formamide
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Abstract
The thermal stabilities of RNA:DNA hybrids are substantially greater than those of DNA:DNA duplexes in aqueous electrolyte solutions containing high concentrations of formamide. Association rates to form DNA:DNA duplexes and DNA:RNA hybrids have been measured in these solvents. There is a temperature range in which DNA:DNA rates are negligible and RNA:DNA rates close to optimal.
Additional Information
© 1977 Oxford University Press. Received December 24, 1976. We are grateful to Drs. Doug Engel and Peter Chandler for their sustained interest and advice and to Dr. Chandler for permission to quote his studies on the stability of RNA in various solvents. This research has been supported by contract No 1 CP 43306 with the Virus Cancer Program of the National Cancer Institute. J.C. has been supported by 1F22 CA03416 from the National Cancer Institute.Attached Files
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Additional details
Identifiers
- PMCID
- PMC343772
- Eprint ID
- 4017
- Resolver ID
- CaltechAUTHORS:CASnar77
Funding
- NIH
- 1 CP 43306
- NIH Postdoctoral Fellowship
- 1F22 CA03416
Dates
- Created
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2006-07-24Created from EPrint's datestamp field
- Updated
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2021-11-08Created from EPrint's last_modified field