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Published November 24, 2005 | public
Journal Article

Reconstruction of genetic circuits


The complex genetic circuits found in cells are ordinarily studied by analysis of genetic and biochemical perturbations. The inherent modularity of biological components like genes and proteins enables a complementary approach: one can construct and analyse synthetic genetic circuits based on their natural counterparts. Such synthetic circuits can be used as simple in vivo models to explore the relation between the structure and function of a genetic circuit. Here we describe recent progress in this area of synthetic biology, highlighting newly developed genetic components and biological lessons learned from this approach.

Additional Information

© 2015 Nature Publishing Group. 24 November 2005. Synthetic biology work in the laboratory is supported by a Burroughs-Wellcome CASI award, The HFSP program and the Searle Scholars program. D.S. would like to acknowledge the support of the Yad Hanadiv Foundation and the CBCD at Caltech. We would like to thank J. W. Chin, C. Guet, S. Leibler, J. Liao, W. Lim, C. Smolke and R. Weiss for contributing figures. We are grateful to R. Kishony, E. Sprinzak, C. Dalal, G. Suel and members of the laboratory for discussions and comments.

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