Welcome to the new version of CaltechAUTHORS. Login is currently restricted to library staff. If you notice any issues, please email coda@library.caltech.edu
Published July 1, 1970 | public
Journal Article Open

Attachment of Carbohydrate to the Variable Region of Myeloma Immunoglobulin Light Chains


Approximately 15 per cent of the light chains from homogeneous immunoglobulins in patients with multiple myeloma contain an oligosaccharide group. Five human myeloma light chains that contained carbohydrate were studied. The sequence [Note: See the image of page 975 for this formatted text] Asn- _ -Ser/Thr was at the site of carbohydrate attachment in all light chains. The carbohydrate group was attached to the asparagine residue of this triplet sequence which in all five light chains was located in the variable region. The occasional occurrence of carbohydrate in myeloma light chains is seen as the consequence of a variable region mutation creating an [Note: See the image of page 975 for this formatted text] Asn- _ -Ser/Thr sequence to which carbohydrate is attached by an enzyme capable of recognizing the characteristic triplet sequence.

Additional Information

Copyright © 1970 by the National Academy of Sciences Communicated by Elvin A. Kabat, April 10, 1970 We wish to thank Dr. Victor Ginsburg for helpful advice and criticism.


Files (1.0 MB)
Name Size Download all
1.0 MB Preview Download

Additional details

August 21, 2023
October 16, 2023