Functional block copolymer nanoparticles: toward the next generation of delivery vehicles
The self-assembly of functional block copolymers (BCPs) into dispersed nanoparticles is a powerful technique for the preparation of novel delivery vehicles with precise control of morphology and architecture. Well-defined BCPs containing an alkyne-functional, biodegradable polylactide (PLA) block were synthesized and conjugated with azide-functional coumarin dyes via copper catalyzed azide alkyne cycloaddition 'click' chemistry. Self-assembled nanoparticles with internal nanophase-separated morphologies could then be accessed by carefully controlling the composition of the BCPs and release of the covalently attached model payload was shown to occur under physiological conditions via the degradation of the PLA scaffold. These results demonstrate the potential of self-assembled nanoparticles as modular delivery vehicles with multiple functionalities, nanostructures, and compartmentalized internal morphology.
Additional Information© Royal Society of Chemistry 2012. Received 5th March 2012, Accepted 3rd April 2012. This project has been funded in part by the National Heart, Lung, and Blood Institute, National Institutes of Health, under Contract No. HHSN268201000046C (L.A.C., N.A.L., and C.J.H.). This work was also supported by the National Science Foundation (MRSEC Program DMR-1121053 (MRL-UCSB) – B.F.L. and C.J.H. and Chemistry Program CHE-0957492 – M.J.R.). M.J.R. thanks the DOE Office of Science for a graduate fellowship.
Accepted Version - nihms643831.pdf
Supplemental Material - c2py20131c.pdf