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Published June 27, 1980 | public
Journal Article

Acetylcholine receptor: complex of homologous subunits


The acetylcholine receptor from the electric ray Torpedo californica is composed of five subunits; two are identical and the other three are structurally related to them. Microsequence analysis of the four polypeptides demonstrates amino acid homology among the subunits. Further sequence analysis of both membrane-bound and Triton-solubilized, chromatographically purified receptor gave the stoichiometry of the four subunits (40,000:50,000:60,000:65,000 daltons) as 2:1:1:1, indicating that this protein is a pentameric complex with a molecular weight of 255,000 daltons. Genealogical analysis suggests that divergence from a common ancestral gene occurred early in the evolution of the receptor. This shared ancestry argues that each of the four subunits plays a functional role in the receptor's physiological action.

Additional Information

© 1980 American Association for the Advancement of Science. 19 February 1980; Revised 18 April 1980. Supported by PHS grants NS 10294 and GM-06965 and by a grant from the Muscular Dystrophy Association of America.

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August 19, 2023
October 19, 2023