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Published March 26, 1998 | Published
Book Section - Chapter Open

Microfabricated devices for sizing DNA and sorting cells


We have microfabricated devices to size and sort microscopic biological objects, ranging from cells to single molecules of DNA. Sizing is accomplished by fluorescent excitation and detection. The devices are fabricated in a silicone elastomer using a replica method. Single molecules of DNA have been sized to 10 percent accuracy, and manipulation of E. Coli cells has been demonstrated.

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© 1998 Society of Photo-Optical Instrumentation Engineers (SPIE). We thank Anne Fu and Frances Arnold for the gift of fluorescent E Coli cells.

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