A gene regulatory network orchestrates neural crest formation
Abstract
The neural crest is a multipotent, migratory cell population that is unique to vertebrate embryos and gives rise to many derivatives, ranging from the peripheral nervous system to the craniofacial skeleton and pigment cells. A multimodule gene regulatory network mediates the complex process of neural crest formation, which involves the early induction and maintenance of the precursor pool, emigration of the neural crest progenitors from the neural tube via an epithelial to mesenchymal transition, migration of progenitor cells along distinct pathways and overt differentiation into diverse cell types. Here, we review our current understanding of these processes and discuss the molecular players that are involved in the neural crest gene regulatory network.
Additional Information
© 2008 Macmillan Publishers Limited. Published online 4 June 2008. We thank S. Bhattacharyya and N. Nikitina for their suggestions and critical reading of the manuscript. This work was supported by California Institute for Regenerative Medicine (CIRM) fellowship to T.S.S. and National Institute of Health (NIH) grants, DE017919 and NS36585, to M.B.F.Additional details
- Eprint ID
- 64830
- Resolver ID
- CaltechAUTHORS:20160229-073228033
- California Institute for Regenerative Medicine (CIRM)
- NIH
- DE017919
- NIH
- NS36585
- Created
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2016-02-29Created from EPrint's datestamp field
- Updated
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2021-11-10Created from EPrint's last_modified field