Enantioselective Michael Spirocyclization of Palladium Enolates

Abstract

Copyright and License

Supplemental Material

The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acscatal.5c02758.

• Cartesian coordinates of the calculated structures (ZIP)

• X-ray data for CCDC 2421482 (CIF)

• X-ray data for CCDC 2421483 (CIF)

• X-ray data for CCDC 2444207 (CIF)

• X-ray data for CCDC 2444208 (CIF)

• Additional experimental and computational details, characterization of new compounds (PDF)

• QM energies and analysis (XLSX)

Data Availability

CCDC Nos. 2421482, 2421483, 2444207, and 2444208 contain the supplementary data for this paper. These data can be obtained free of charge via http://www.ccdc.cam.ac.uk/data_request/cif, or by emailing data_request@ccdc.cam.ac.uk, or by contacting The Cambridge Crystallographic Data Centre, 12 Union Road, Cambridge CB2 1EZ, UK; fax: + 44 1223 336033.

Conflict of Interest

The authors declare no competing financial interest.

Acknowledgement

The NIH-NIGMS (No. R35GM145239), Heritage Medical Research Investigators Program, and Caltech are thanked for the support of our research program. We also thank Dr. David VanderVelde (Caltech) for his NMR expertise, Dr. Mona Shahgoli, Dr. Scott C. Virgil, and Dr. Jay P. Barbor (Caltech) for their assistance with mass spectrometry and other instrumentation, Dr. Michael K. Takase (Caltech) for assistance and expertise with X-ray crystallography. The authors extend additional thanks to Prof. Alexander Q. Cusumano, Kevin J. Gonzalez, and Dr. Elliot F. Hicks for helpful discussions. C.S.S. and P.C. would like to thank the NSF GRFP for funding. W.A.G. thanks the NSF (No. CBET 2311117) for support. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the National Science Foundation. The authors thank the Caltech High Performance Computing Center for support.