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Published February 22, 2011 | Published
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Second generation optical-resolution photoacoustic microscopy


We developed a second-generation optical-resolution photoacoustic microscope (OR-PAM) with a novel acoustic detection scheme, which improved upon the sensitivity of our first-generation system by 18 dB. Moreover, translating the imaging head instead of the living object improved the scanning speed by a factor of 5, widening the field of view within the same acquisition time. The anatomy and hemoglobin oxygen saturation of an entire mouse ear was imaged in vivo.

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© 2011 Society of Photo-Optical Instrumentation Engineers.

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