Welcome to the new version of CaltechAUTHORS. Login is currently restricted to library staff. If you notice any issues, please email coda@library.caltech.edu
Published October 4, 2010 | Accepted Version + Supplemental Material
Journal Article Open

Chemistries for Patterning Robust DNA MicroBarcodes Enable Multiplex Assays of Cytoplasm Proteins from Single Cancer Cells


The optimization of chemistries to enable the patterning of miniaturized DNA barcodes using microfluidics flow channels is described (see picture). Experiment and theory reveal that solvent mixtures in which counterions are strongly associated with the negatively charged DNA oligomers may be harnessed to produce high quality, high density DNA microarray patterns over a large area.

Additional Information

© 2010 Wiley-VCH Verlag GmbH& Co. KGaA, Weinheim. Received: July 1, 2010. Published online on August 16, 2010. This work was supported by National Cancer Institute Grant No. 5U54 CA119347 (J.R.H., P.I.) and by a gift from the Jean Perkins Foundation. H. K, T. A. P and W. A. G also acknowledge support from the WCU programs through NRF of Korea funded by the MEST (R31–2008–000–10055–0).

Attached Files

Accepted Version - nihms478904.pdf

Supplemental Material - cphc_201000528_sm_miscellaneous_information.pdf


Files (2.6 MB)
Name Size Download all
1.9 MB Preview Download
731.4 kB Preview Download

Additional details

August 22, 2023
October 20, 2023