Signal and noise in ultrasound-modulated optical tomography: a Monte Carlo study
Ultrasound-modulated optical tomography in inhomogeneous scattering media was studied using a Monte Carlo modeling technique. The contributions from two different modulation mechanisms were included in the simulation. The differences between embedded absorption and scattering objects in the ultrasound-modulated optical signals were compared. The effects of neighboring inhomogeneity and background optical properties on the ultrasound-modulated optical signals were also studied. We analyzed the signal-to-noise ratio in the experiment and found that the major noise source is the speckle noise caused by small particle movement within the biological tissue sample. This effect was studied by incorporating a Brownian motion factor in the simulation.
Additional Information© 2004 Society of Photo-Optical Instrumentation Engineers (SPIE). This project was sponsored by a Summer Faculty Resaerch Fellowship support (for Yao Gang) from University of Missouri-Columbia; and in part (for Wang) by National Institutes of Health grants R29 CA68562 and R01 CA71980, National Science Foundation grant BES-9734491, and Texas Higher Education Coordinating Board grant 000512-0063-2001.
Published - 156.pdf