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Published March 2009 | Published
Journal Article Open

Ultrasound-modulated optical tomography in reflection mode with ring-shaped light illumination


We have succeeded in implementing ring-shaped light illumination ultrasound-modulated optical tomography (UOT) in reflection mode. The system used intense acoustic bursts and a charge-coupled device (CCD) camera-based speckle contrast detection method. In addition, the implementation allows placing the tissue sample below (not within) an acoustic coupling water tank and scanning the tissue without moving the sample. Thus, the UOT system is more clinically applicable than previous transmission-mode systems. Furthermore, we have successfully imaged an ex vivo methylene-blue-dyed sentinel lymph node (SLN) embedded at a depth of 13mm in chicken breast tissue. This UOT system offers several advantages: noninvasiveness, nonionizing radiation, portability, cost effectiveness, and the possibility of combination with ultrasound pulse-echo imaging and photoacoustic imaging. One potential application of the UOT system is mapping SLNs in axillary staging for breast cancer patients.

Additional Information

© 2009 SPIE. Paper 08349R received Oct. 1, 2008; revised manuscript received Dec. 30, 2008; accepted for publication Jan. 15, 2009; published online Mar. 6, 2009. This research was supported by NIH Grant No. R33 CA 094267.

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