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Published August 19, 1983 | public
Journal Article

Nucleotide Sequence of a Light Chain Gene of the Mouse I-A Subregion: Aβ^d


Iɑ (I region-associated) antigens are cell-surface glycoproteins involved in the regulation of immune responsiveness. They are composed of one heavy (ɑ) and one light (β) polypeptide chain. We have sequenced the gene encoding the Aβ^d chain of the BALB/c mouse. The presence of six exons is predicted by comparison with the complementary DNA sequences of human β chains and with partial protein sequence data for the Aβ^d polypeptide. Sequence comparisons have been made to other proteins involved in immune responses and the consequent implications for the evolutionary relationships of these genes are discussed.

Additional Information

© 1983 American Association for the Advancement of Science. 16 June 1983. We thank M. Steinmetz for his help during the initiation of this work, K. Minard for preparation of the sequencing gels, and B. Larsh and S. Olive for preparation of the manuscript. Supported in part by NIH grants (L.H.) and by the Fondation pour la Recherche Medicale (M.M.).

Additional details

August 19, 2023
October 20, 2023