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Published April 21, 2014 | Supplemental Material + Published + Accepted Version
Journal Article Open

Plasmonics-enhanced and optically modulated delivery of gold nanostars into brain tumor


Plasmonics-active gold nanostars exhibiting strong imaging contrast and efficient photothermal transduction were synthesized for a novel pulsed laser-modulated plasmonics-enhanced brain tumor microvascular permeabilization. We demonstrate a selective, optically modulated delivery of nanoprobes into the tumor parenchyma with minimal off-target distribution.

Additional Information

© 2014 The Royal Society of Chemistry. The article was received on 21 Dec 2013, accepted on 26 Feb 2014 and first published on 04 Mar 2014. This work was supported in part from the National Institutes of Health (Grant R01 EB006201, T32 EB001040, 5K08-NS075144-03, DP1 EB016986, R01 EB016963), the Department of Defense (DOD Award W81XWH-09-1-0064), the Defense Advanced Research Projects Agency (HR0011-13-2-0003), the Duke Exploratory Research Funds, and National Children's Research Centre (NCRC) Funds. The content of the information does not necessarily reflect the position or the policy of the Government, and no official endorsement should be inferred. L.W. has a financial interest in Microphotoacoustics, Inc. and Endra, Inc., which, however, did not support this work. The authors would like to thank Dr Darell Bigner and the Duke Preston Robert Tisch Brain Tumor Center for their support of the human brain tumor xenografts used in the orthotopic mouse models, as well as Dr Sam Johnson and the Duke Light Microscopy Core Facility for their expertise in multiphoton microscopy.

Attached Files

Published - c3nr06770j.pdf

Accepted Version - nihms581535.pdf

Supplemental Material - c3nr06770j1_si.pdf


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August 20, 2023
October 20, 2023