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Published October 1, 1981 | public
Journal Article Open

Effect of surface modification on aggregation of phospholipid vesicles


Phospholipid vesicles have been extensively investigated because of their usefulness as models for biological membranes and their potential application as carriers for drug delivery. However, preparations of small sonicated vesicles tend to aggregate and fuse (on storage at room temperature and at 4 degrees C), resulting in significant changes in turbidity, rate of uptake by macrophage, and proton NMR linewidths. By modification of the surface of phospholipid vesicles with charged groups such as ß - aminogalactose that extend significantly from the vesicle surface, it is possible to obtain preparations that are stable for >7 days.

Additional Information

Copyright © 1981 by the National Academy of Sciences. Contributed by John D. Baldeschwieler, June 10, 1981. Helpful discussions with Professor Sunney I. Chan are gratefully acknowledged. The proton NMR spectra were obtained at the Southern California Regional NMR Facility, California Institute of Technology, Pasadena, CA, with the assistance of Dr. William R. Croasmun and Uptal Banerjee. This research was supported by grants from the National Science Foundation (CHE79-18401) and the National Institutes of Health (GM21111-09) and a grant from Merck. This is contribution no. 6449 from the Arthur Amos Noyes Laboratory of Chemical Physics. The publication costs ofthis article were defrayed in part by page charge payment. This article must therefore be hereby marked "advertisenent" in accordance with 18 U. S. C. §1734 solely to indicate this fact.


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