Measurement of Grüneisen parameter of tissue by photoacoustic spectrometry
The Grüneisen parameter of tissue is a constitutive parameter in photoacoustic tomography. Here, we applied photoacoustic spectrometry (PAS) to directly measure the Grüneisen parameter. In our PAS system, laser pulses at wavelengths between 460 and 1600 nm were delivered to tissue samples, and photoacoustic signals were detected by a 20 MHz flat water-immersion ultrasonic transducer. By fitting photoacoustic spectra to light absorption spectra, we found that the Grüneisen parameter was 0.73 for porcine subcutaneous fat tissue, and 0.15 for oxygenated bovine red blood cells at room temperature (24°C).
Additional Information© 2013 Society of Photo-Optical Instrumentation Engineers (SPIE). This work was sponsored in part by National Institutes of Health grants R01 EB000712, R01 EB008085, R01 CA113453901, U54 CA136398, 5P60 DK02057933, and U54 CA136398. L.W. has a financial interest in Microphotoacoustics, Inc. and Endra, Inc., which, however, did not support this work.
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