Intracranial electrical stimulation alters meso-scale network integration as a function of network topology
Abstract
Human brain dynamics are organized into a multi-scale network structure that contains multiple tight-knit, meso-scale communities. Recent work has demonstrated that many psychological capacities, as well as impairments in cognitive function secondary to damage, can be mapped onto organizing principles at this mesoscopic scale. However, we still don't know the rules that govern the dynamic interactions between regions that are constrained by the topology of the broader network. In this preregistered study, we utilized a unique human dataset in which whole brain BOLD-fMRI activity was recorded simultaneously with intracranial electrical stimulation, to characterize the effects of direct neural stimulation on the dynamic reconfiguration of the broader network. Direct neural stimulation increased the extent to which the stimulation site's own mesoscale community integrated with the rest of the brain. Further, we found that these network changes depended on the topological role of the stimulation site itself: stimulating regions with high participation coefficients led to global integration, whereas stimulating sites with low participation coefficients integrated that regions' own community with the rest of the brain. These findings provide direct causal evidence for how network topology shapes and constrains inter-regional coordination, and suggest applications for targeted therapeutic interventions in patients with deep-brain stimulation.
Additional Information
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC 4.0 International license. This version posted January 19, 2021. Funded by NIH grant U01NS103780 (RP, RA), The Simons Foundation Collaboration on the Global Brain (RA), Knut and Alice Wallenberg Foundation grant 2016.0473 (WHT), National Health and Medical Research Council 1156536 (JMS), Swiss National Science Foundation PZ00P2_185872 (OE). This work was conducted on an MRI instrument funded by National Institute of Health grant 1S10OD025025-01. Code analysis: The entire code for the project can be found at https://github.com/wiheto/esfmri_connectivity under a Apache-2.0 License. Further, this repository has been linked to the preregistration at OSF, and all pull requests can be tracked seeing all the changes made.Attached Files
Submitted - 2021.01.16.426941v1.full.pdf
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Additional details
- Eprint ID
- 110667
- Resolver ID
- CaltechAUTHORS:20210831-204705170
- NIH
- U01NS103780
- Simons Foundation
- Knut and Alice Wallenberg Foundation
- 2016.0473
- National Health and Medical Research Council (NHMRC)
- 1156536
- Swiss National Science Foundation (SNSF)
- PZ00P2_185872
- NIH
- 1S10OD025025-01
- Created
-
2021-08-31Created from EPrint's datestamp field
- Updated
-
2021-11-16Created from EPrint's last_modified field
- Caltech groups
- Division of Biology and Biological Engineering