Optical-resolution photoacoustic microscopy of the metabolic rate of oxygen in a mouse renal tumor model
We propose using noninvasive longitudinal optical-resolution photoacoustic microscopy (L-ORPAM) to quantify blood flow flux, oxygen saturation (sO_2), and thereby the metabolic rate of oxygen (MRO_2), for a renal tumor model in the same mouse over weeks to months. Experiments showed that the sO2 difference between the artery and vein decreased greatly due to the arteriovenous shunting effect during tumor growth. Moreover, hypermetabolism was exhibited by an increase in MRO_2.
Additional Information© 2015 Society of Photo-Optical Instrumentation Engineers. The authors appreciate the close reading of the manuscript by Prof. James Ballard. We also thank Junjie Yao for helpful discussions. This work was sponsored by National Institutes of Health Grants DP1 EB016986 (NIH Director's Pioneer Award), R01 CA186567 (NIH Director's Transformative Research Award), R01 CA159959, and R01 EB016963. L.V.W. has financial interests in Microphotoacoustics, Inc. and Endra, Inc., neither of which supported this work. K. Maslov has a financial interest in Microphotoacoustics, Inc.
Published - 93233H.pdf