A parylene-based microelectrode array implant for spinal cord stimulation in rats
The design and fabrication of an epidural spinal cord implant using a parylene-based microelectrode array is presented. Rats with hindlimb paralysis from a complete spinal cord transection were implanted with the device and studied for up to eight weeks, where we have demonstrated recovery of hindlimb stepping functionality through pulsed stimulation. The microelectrode array allows for a high degree of freedom and specificity in selecting the site of stimulation compared to wire-based implants, and triggers varied biological responses that can lead to an increased understanding of the spinal cord and locomotion recovery for victims of spinal cord injury.
Additional Information© 2011 IEEE. Date Added to IEEE Xplore: 17 March 2011. This research was funded by NIH BRP grant R01-EB0076151 and DoD TATRC grant W81XWH-09-2-0024. The authors would also like to thank Trevor Roper and all our colleagues at the Caltech Micromachining Lab and the Edgerton Lab at UCLA.
Accepted Version - nihms312942.pdf