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Published August 7, 2011 | Published + Supplemental Material
Journal Article Open

A rapid and convergent synthesis of the integrastatin core


The tetracyclic core of the integrastatin natural products has been prepared in a convergent and rapidmanner. Our strategy relies upon a palladium(II)-catalyzed oxidative cyclization to form the central [3.3.1]-dioxabicycle of the natural product core. Overall, the core has been completed in only 4 linear steps from known compounds.

Additional Information

© 2011 The Royal Society of Chemistry. Received 8th May 2011, Accepted 26th May 2011. First published on the web 26 May 2011. This publication is based on work supported by Award No. KUS-11-006-02, made by King Abdullah University of Science and Technology (KAUST). Financial support from Caltech, the Rose Hills Foundation (undergraduate fellowship to P.B.), and the California HIV/AIDS Research Program (graduate fellowship to P.M.T.) is also gratefully acknowledged.

Attached Files

Published - Tadross2011p15428Org_Biomol_Chem.pdf

Supplemental Material - c1ob05725a.pdf


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