Published August 7, 2011
| Published + Supplemental Material
Journal Article
Open
A rapid and convergent synthesis of the integrastatin core
Abstract
The tetracyclic core of the integrastatin natural products has been prepared in a convergent and rapidmanner. Our strategy relies upon a palladium(II)-catalyzed oxidative cyclization to form the central [3.3.1]-dioxabicycle of the natural product core. Overall, the core has been completed in only 4 linear steps from known compounds.
Additional Information
© 2011 The Royal Society of Chemistry. Received 8th May 2011, Accepted 26th May 2011. First published on the web 26 May 2011. This publication is based on work supported by Award No. KUS-11-006-02, made by King Abdullah University of Science and Technology (KAUST). Financial support from Caltech, the Rose Hills Foundation (undergraduate fellowship to P.B.), and the California HIV/AIDS Research Program (graduate fellowship to P.M.T.) is also gratefully acknowledged.Attached Files
Published - Tadross2011p15428Org_Biomol_Chem.pdf
Supplemental Material - c1ob05725a.pdf
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Tadross2011p15428Org_Biomol_Chem.pdf
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Additional details
- Eprint ID
- 24731
- Resolver ID
- CaltechAUTHORS:20110808-112210599
- King Abdullah University of Science and Technology (KAUST)
- KUS-11-006-02
- Caltech
- Rose Hills Foundation
- California HIV/AIDS Research Program
- Created
-
2011-10-24Created from EPrint's datestamp field
- Updated
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2021-11-09Created from EPrint's last_modified field