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Published March 1942 | Published
Journal Article Open

The synthesis of D-erythro- and D-threo-α-amino-β,γ-dihydroxy-n-butyric acids


We repeated the synthesis of Fischer and Feldmann [2] and obtained, as they did, the amino acid with [α]D24 = -13.7° in good yield. However, in addition another α-amino-β,γ-dihydroxy-n-butyric acid, with [α]D24 = 16.0°, was isolated from the reaction mixture. It is the purpose of this communication to show that the amino acid with [α]D24 = -13.7° is not a mixture of disastereoisomers, but is D-threo-α-amino-β,γ-dihydroxy-n-butyric acid, and that the amino acid with [α]D24 = 16.0° is D-erythro-α-amino-β,γ-dihydroxy-n-butyric acid.

Additional Information

Copyright © 1942 by the American Society for Biochemistry and Molecular Biology. (Received for publication, December 8, 1941) We wish to thank Mr. Erik Heegaard for his assistance in connection with these experiments.

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