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Published March 2002 | public
Journal Article

Evaluation of the energetic contribution of an ionic network to beta-sheet stability


We have evaluated the interaction energy of a three-residue ionic network constructed on the β-sheet surface of protein G using double mutant cycles. Although the two individual ion pairs were each stabilizing by ~0.6 kcal/mol, the excess gain in stability for the triad was small (0.06 kcal/mol).

Additional Information

© 2002 The Protein Society. Received June 19, 2001; Accepted November 30, 2001. Article first published online: 13 Apr. 2009.

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