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Published March 1, 2004 | Published
Journal Article Open

Ultrasound-modulated optical computed tomography of biological tissues


An optical imaging technique called ultrasound-modulated optical computed tomography is demonstrated for tomographic imaging of biological tissues. Ultrasound-modulated optical signals are extracted from scattered light to provide projection data for the image reconstruction. A filtered back-projection algorithm is implemented to reconstruct an image reflecting optical tissue properties from angular and linear scans of an ultrasonic beam across a sample. This reconstruction-based imaging technique provides a way to obtain images of cross sections containing the scanned ultrasonic axis in biological tissues, which enables three-dimensional ultrasound-modulated optical imaging. The technique combines the contrast advantage of optical waves and the resolution advantage of ultrasonic waves.

Additional Information

© 2004 American Institute of Physics. Received 12 August 2003; accepted 31 December 2003. This project was sponsored in part by National Science Foundation Grant No. BES-9734491; Texas Higher Education Coordinating Board Grant No. 000512-0063-2001; and National Institutes of Health Grant No. R01 EB000712.

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