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Published August 11, 2008 | Supplemental Material + Accepted Version
Journal Article Open

Palladium-Catalyzed Enantioselective Oxidation of Chiral Secondary Alcohols: Access to Both Enantiomeric Series


Rapid resolution: A new catalyst system for the oxidative kinetic resolution of secondary alcohols leads to dramatic rate increases. This system allows the use of a diamine to provide access to either enantiomer of a range of alcohols with good selectivity factors (see scheme). This method has been applied to the formal total synthesis of (−)-amurensinine.

Additional Information

© 2008 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. Received: April 22, 2008; Published online: July 14, 2008. We are grateful to the NIH-NIGMS (R01 GM65961-01), NSF (predoctoral fellowship to D.C.E.), NDSEG (predoctoral fellowship to D.C.E.), Bristol-Myers Squibb and the American Chemical Society (predoctoral fellowship to R.M.T.), EPSRC, and EU.

Attached Files

Accepted Version - nihms54998.pdf

Supplemental Material - anie_200801865_sm_miscellaneous_information.pdf


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